CRISPR Technology — Key Discoveries

Key Discoveries

Jinek et al. (2012) - Foundational CRISPR-Cas9 Mechanism

2012

This seminal paper, published in Science by Martin Jinek, Krzysztof Chylinski, Emmanuelle Charpentier, Jennifer Doudna, and colleagues, was the first to demonstrate that the…

Cong et al. (2013) - First Mammalian Cell Editing

2013

Published in Science by Le Cong, Feng Zhang, and colleagues, this paper, almost simultaneously with another by George Church's group, reported the successful application of the…

Gaudelli et al. (2017) - Development of Adenine Base Editor (ABE)

2017

Published in Nature by Nicole Gaudelli, David Liu, and colleagues, this paper introduced the Adenine Base Editor (ABE), a revolutionary CRISPR 2.0 technology. ABE enables the…