Gene Therapy — Prelims Strategy

Prelims Strategy

For Prelims, a strong foundation in the basics of gene therapy is essential. Focus on understanding the 'what,' 'how,' and 'why' of each component. Memorize the names of key viral vectors (AAV, Lentivirus, Adenovirus) and their distinguishing characteristics (e.

g., immunogenicity, integration, cargo capacity). Be familiar with prominent examples of approved gene therapies (Zolgensma, Luxturna, Casgevy) and the diseases they treat. Pay close attention to India-specific regulatory bodies (ICMR, CDSCO) and their guidelines, particularly the New Drugs and Clinical Trials Rules, 2019.

Differentiate clearly between somatic and germline gene therapy, and understand why germline therapy is prohibited. A crucial aspect is distinguishing gene therapy from gene editing (CRISPR-Cas9) – know their mechanisms and applications.

Create flashcards for key terms, definitions, and examples. Practice MCQs that test conceptual understanding and factual recall, especially those with options designed to trap by mixing characteristics of different vectors or therapies.

Current affairs related to new approvals or major clinical trial announcements (especially in India) are high-yield areas. Vyyuha's advice: focus on the 'who, what, where, when' for Prelims, linking scientific terms to their practical applications and regulatory context.